The Tigers lead 33-0 at halftime after scoring on their first four possessions and adding a safety and field goal in the second quarter.
Freshman tailback Henry Josey was the story of the first half, racking up 108 yards and scoring three touchdowns on just five carries.
Junior quarterback Blaine Gabbert was nearly perfect for the Missouri passing game, complete 24 of his 27 passing attempts in the half for 190 yards through the air.
Junior tailback De'Vion Moore leads the backfield with six carries, one of which resulted in a nine-yard touchdown run.
Redshirt freshman defensive end Michael Sam took advantage of his playing time, recording a sack and safety for two more Tiger points.
The Tigers will start the half on defense as the Cowboys deferred after winning the coin toss.